(DOWNLOAD) "Molecular Targets in Protein Misfolding and Neurodegenerative Disease" by Pierfausto Seneci * eBook PDF Kindle ePub Free
eBook details
- Title: Molecular Targets in Protein Misfolding and Neurodegenerative Disease
- Author : Pierfausto Seneci
- Release Date : January 07, 2014
- Genre: Life Sciences,Books,Science & Nature,Professional & Technical,Medical,Pharmacology & Toxicology,Biology,
- Pages : * pages
- Size : 16657 KB
Description
Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.
Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseasesProvides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potentialProvides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical developmentProvides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease areaContains a more thorough description of the therapeutic relevance of ~10 specific molecular targets